SSD114 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SSD114 盐酸盐是一种 GABAB 受体正变构调节剂。

SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.

In the presence of 10 μM GABA, SSD114 hydrochloride at 25 μM significantly increases (to approximately 170% above basal levels) the [35S]GTPγS stimulation induced by GABA alone. SSD114 hydrochloride, added at 15 and 30 μM, induces a leftward shift of the GABA concentration-response curve with a slight concomitant increase of maximal GABA stimulation at the highest concentration. In the presence of both 15 and 30 μM SSD114 hydrochloride, the EC50 for GABA decreases by 2 and 2.5 fold, respectively, while the maximal stimulation (Emax) is potentiated only at the concentration of 30 μM, reaching 161±5.09% over the basal value .

The onset of loss of righting reflex (LORR) is reduced by pretreatment with SSD114 hydrochloride [F(5,30)=4.55, P<0.005]. Post hoc analysis indicates that the onset of LORR is significantly lower in mouse groups pretreated with doses of SSD114 hydrochloride equal to or higher than 10 mg/kg than in vehicle-treated mice. The duration of LORR is increased by pretreatment with SSD114 hydrochloride [F(5,30)=4.81, P<0.005]. Post hoc analysis indicates that the duration of LORR is significantly longer in mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride than in vehicle-treated mice.

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Others

Other Targets

GABA

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2319790-02-6

387.83

C18H21ClF3N3O

>98% (HPLC)

DMSO:130 mg/mL (335.20 mM; Need ultrasonic)

Cl.COc1cc(nc(NC2CCCCC2)n1)-c1ccc(cc1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years